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Doctors widely prescribe Eliquis (apixaban). It’s an anticoagulant used to prevent blood clots and reduce the risk of stroke. It’s for patients with conditions like atrial fibrillation. It is effective for these conditions. But, you must consider diet to ensure it works and to reduce complications. Some foods and habits can interact with blood thinner medication. They can affect its efficacy and raise the risk of side effects. You must understand what foods to avoid while on Eliquis. This is crucial for staying healthy and safe. This guide helps you make informed food choices while on medication therapy. It offers practical advice and valuable tips.

How Does Eliquis Work?

Eliquis (apixaban) is an anticoagulant. It is commonly called a blood thinner. It helps prevent the formation of harmful blood clots. It is very good at reducing the risk of stroke. It also treats conditions such as atrial fibrillation, deep vein thrombosis (DVT), and pulmonary embolism (PE). Understanding Eliquis’s workings can give insight into its role in managing these conditions. It also shows the importance of sticking to prescribed treatment.

It functions by inhibiting Factor Xa, an essential protein in the coagulation cascade. The coagulation cascade is a series of steps that the body uses to form blood clots in response to injury. Factor Xa is crucial in this process. It converts prothrombin into thrombin, an enzyme needed for fibrin clot formation. It blocks Factor Xa. This reduces thrombin generation, stopping fibrin clot formation.

Benefits of Eliquis

ECG result for Eliquis medication

  • It prevents blood clots. It does this by blocking Factor Xa. This stops new clots from forming and existing ones from growing.

  • It significantly lowers stroke risk. Atrial fibrillation patients face this risk. It is a common and serious complication linked to irregular heartbeats.

  • It treats and prevents DVT and PE. It works for both the treatment and prevention of these conditions. They can be life-threatening if not treated.

  • It offers predictable anticoagulant effects. This reduces the need for frequent blood monitoring and dose adjustments. It’s unlike traditional anticoagulants like warfarin.

What Food to Avoid While on Eliquis

  1. Grapefruit and Grapefruit Juice

Grapefruit and its juice can inhibit the enzyme CYP3A4, which is crucial for the metabolism of Eliquis. To avoid such risks, it is recommended to steer clear of grapefruit and grapefruit juice while on medication. If these are staples in your diet, you must ask your healthcare provider for personalized advice. Discuss any alternatives that won’t interfere with your medication.

  1. Alcohol

Drinking too much alcohol can greatly raise the risk of gastrointestinal bleeding. This is a known side effect of Eliquis. Also, alcohol can harm liver function. The liver is vital for metabolizing Eliquis. This can lead to side effects or reduced effectiveness of the medication. To mitigate these risks, it is advisable to limit alcohol intake and avoid binge drinking. You must talk to your healthcare provider about how much alcohol is safe while taking Eliquis. This will help you manage your health and avoid problems.

  1. Green Leafy Vegetables

Monitoring vegetable intake is less critical with Eliquis than with warfarin. It applies to green leafy vegetables like spinach, kale, and broccoli. But, it’s still important to be aware of their high vitamin K. Vitamin K helps blood clotting. Although its impact on medication is less, it’s good to keep intake consistent. Sudden changes in vitamin K consumption can affect the medication’s effectiveness. To manage your health best, tell your healthcare provider about your typical diet. Also, tell them about any big changes involving these vegetables.

  1. Herbal Supplements

Certain herbal supplements can interact with Eliquis, affecting its effectiveness. For example, St. John’s Wort can either increase or decrease Eliquis’ efficacy. Other supplements, such as ginkgo biloba, garlic, and ginger, can raise bleeding risks. They do this when combined with anticoagulants. To stay safe and to keep blood thinner medication working, avoid taking herbal supplements. Ask your healthcare provider first. They can advise on potential interactions and safe usage. This helps you manage your health well. It also lowers the risk of side effects from the supplements.

  1. Excessive Vitamin E

High doses of vitamin E can exert an anticoagulant effect, which may increase the risk of bleeding when taken in conjunction with blood thinner medication. This potential interaction shows the importance of managing your vitamin E intake. You must do so carefully while on this medication. To avoid complications, it is advisable to steer clear of high-dose vitamin E supplements. Also, always discuss over-the-counter supplements with your doctor. This will ensure they do not interfere with your medication treatment. Your healthcare provider can give you personalized advice. It can help you safely add supplements to your routine.

Which Foods Are Good for Eating on Eliquis?

Now that we know which foods to avoid while taking Eliquis, it’s important to understand what foods to include in your diet. Maintaining a healthy diet will support your heart and overall well-being while on medication. A great option is to focus on a plant-based diet, such as the Mediterranean diet. When planning your meals, be sure to include:

  1. Heart-Healthy Fats: Fatty Acids (Omega-3)

Heart-Healthy Fats (Omega-3 Fatty Acids) They are good for the heart. They stop blood platelets from clumping, thus preventing clots. These healthy fats can be found in:

  • Fatty fish like salmon, sardines, and mackerel

  • Chia seeds

  • Walnuts

  • Flaxseeds

  • Cod liver oil

Oysters are high in omega-3s. But, be careful when combining high doses of omega-3s with medication. It may raise the risk of severe bleeding. So, before considering omega-3 or fish oil supplements, ask your healthcare provider. They can give you personalized dietary recommendations.

  1. Fruits and Vegetables

Eating fruits and vegetables is a great boon for your health! They boast abundant fiber and vital nutrients such as folate, vitamin C, and potassium. Also, they’re rich in antioxidants. Antioxidants are the body’s guards against inflammation. They promote longevity. But the advantages don’t end there! They also help artery health. They prevent plaque buildup and lower the risk of strokes and heart attacks. Therefore, indulging in a variety of greens and fruits isn’t just delicious—it’s a savvy strategy to maintain a robust heart and well-being.

  1. Legumes and Lean Protein

Legumes, such as lentils and beans, are abundant in dietary fiber. This fiber is great at reducing LDL cholesterol. LDL is the “bad” cholesterol. It lowers LDL levels. This reduces the buildup of fat in your arteries. It ensures smooth blood flow for good health. When it comes to protein intake, selecting sources low in saturated fat is preferable. Choose lean beef and pork, skinless chicken, and fish. They have the needed protein, but not the excess saturated fat that harms health.

What Vitamins Should You Not Take with Eliquis?

When you’re on medication, some vitamins and supplements might not mix well with it. One such vitamin is vitamin K, which helps blood clot. Eating foods with vitamin K, like leafy greens, is good. But, taking too many vitamin K pills can mess with blood thinner medication. Also, be careful with herbal supplements. Examples are St. John’s Wort or garlic.  Another thing to watch out for is vitamin E pills, especially if they’re high doses. They can also make bleeding more likely when taken with blood thinner medication. Fish oil pills and some multivitamins can do the same thing. It’s best to talk to your doctor before taking any of these while on Eliquis. They can help you stay safe and healthy while on your medication.

What Drugs Interact Badly with Eliquis?

Several drugs can interact badly with Eliquis (apixaban), affecting its effectiveness or increasing the risk of side effects. It’s essential to inform your healthcare provider about all medications you are taking, including prescription drugs, over-the-counter medications, and supplements, to avoid potential interactions. Some drugs that may interact with Eliquis include:

Anticoagulants and Antiplatelet Drugs

Taking other blood-thinning drugs with Eliquis, such as warfarin and heparin, and aspirin, clopidogrel, ibuprofen, and naproxen can increase the risk of bleeding. These drugs interfere with the blood’s clotting ability. This raises the risk of bleeding. Tell your healthcare provider about these medications. They may need to adjust your Eliquis dose or watch for bleeding signs.

Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)

Some antidepressants are fluoxetine (Prozac), sertraline (Zoloft), and venlafaxine (Effexor). They are SSRIs and SNRIs. They can raise the risk of bleeding when used with blood thinner medication. These drugs affect serotonin in the brain. They can disrupt blood clotting, causing bleeding.

Antifungal Medications

Some antifungal medications, like ketoconazole and itraconazole, can disrupt Eliquis’ metabolism. This raises the medication’s blood levels. This increase in Eliquis concentration can heighten the risk of bleeding complications. You must tell your healthcare provider if you are prescribed antifungal drugs while taking Eliquis. This is key to ensuring the right monitoring and management of your treatment.


Some antibiotics, like erythromycin and clarithromycin, can interact with Eliquis. They affect its metabolism and raise the risk of bleeding. These antibiotics may stop the body from processing Eliquis. This can lead to higher blood levels of the medication. As a result, the risk of bleeding complications may increase.

HIV Protease Inhibitors

HIV protease inhibitors, such as ritonavir and lopinavir/ritonavir, may interact with Eliquis. They can raise blood levels and the risk of bleeding. These medications are used in HIV treatment. They can interfere with the metabolism of Eliquis. This leads to higher drug levels in the blood. As a consequence, the likelihood of experiencing bleeding complications may escalate.

Can You Drink Coffee with Eliquis?

Yes, moderate coffee consumption is generally considered safe while taking Eliquis (apixaban). Coffee won’t directly interact with Eliquis. But, too much caffeine can raise heart rate. This can worry people with heart issues.

What Spices to Avoid While Taking Eliquis?

While there are no specific spices that are known to interact directly with Eliquis (apixaban), it’s essential to be cautious with spices that may have blood-thinning properties or affect blood clotting. Some spices that are commonly associated with potential blood-thinning effects include:

  1. Turmeric: This spice contains curcumin, which has been reported to have anticoagulant properties and may interfere with blood clotting mechanisms.

  2. Ginger: Ginger has natural blood-thinning properties and may affect platelet function, potentially increasing the risk of bleeding.

  3. Garlic: Garlic is believed to have mild anticoagulant effects and may interact with blood-thinning medications like Eliquis.

While these spices are commonly used in cooking and are generally safe for consumption in culinary amounts, it’s essential to use them in moderation, especially if you are taking Eliquis or other anticoagulant medications.

Does Vitamin D3 Interfere with Eliquis?

There is no significant evidence to suggest that vitamin D3 directly interferes with Eliquis (apixaban) or affects its effectiveness. Vitamin D3 is a crucial nutrient that plays a vital role in bone health, immune function, and overall well-being. Vitamin D supplements are safe and helpful for many people. But, it’s essential to talk to your healthcare provider before starting or stopping any supplements, including vitamin D3, while taking blood thinner medication.

Vitamin D3 is unlikely to interact with Eliquis. But, it’s best to ask your healthcare provider for advice. This is especially true if you have health conditions or concerns.

Why Is Eliquis So Expensive

Eliquis (apixaban) may be expensive for several reasons:

Brand-Name Medication

It is a brand-name medication, meaning it is manufactured and sold by the pharmaceutical company Bristol Myers Squibb. Brand-name drugs tend to be more expensive than their generic counterparts because the company invests in research, development, marketing, and patent protection for the drug.

Limited Competition

Eliquis may have limited competition from other medications in its class. When there are fewer alternatives available, drug manufacturers may be able to set higher prices for their products.

Insurance Coverage

The cost of Eliquis may also depend on your insurance coverage. Some insurance plans may cover more of the cost of Eliquis, while others may require higher out-of-pocket expenses.

Supply Chain Costs

The cost of manufacturing, distributing, and dispensing Eliquis also contributes to its overall price. This includes expenses related to production, packaging, transportation, and pharmacy dispensing fees.

Research and Development

The cost of developing and testing new medications, including Eliquis, is significant. Pharmaceutical companies often factor these costs into drug prices. They do this to make back their investments.

Market Demand

The demand for Eliquis may also influence its price. If there is a high demand for the medication due to its effectiveness and safety profile, the manufacturer may be able to set a higher price for it.

Eliquis Dosage for Elderly

Doctors usually recommend the same Eliquis dosage for elderly patients as for younger adults. This is true if there are no specific reasons not to or no big other health problems.It has a standard dosage for most uses. They include preventing stroke in atrial fibrillation. They also treat or prevent deep vein thrombosis (DVT) and pulmonary embolism (PE). The dosage is:

  • Atrial Fibrillation: The usual dose is 5 mg taken orally twice daily. However, the dose may be reduced to 2.5 mg twice daily in elderly patients with at least two of the following criteria: age 80 years or older, body weight 60 kg or less, or serum creatinine level 1.5 mg/dL or higher.

  • Treatment or Prevention of DVT/PE: The standard dose is 10 mg taken orally twice daily for the first 7 days, followed by 5 mg taken orally twice daily thereafter. Elderly patients with renal impairment may require dosage adjustments based on their kidney function.

Is There a Generic for Eliquis

The generic name for Eliquis is apixaban. However, currently, there is no generic version of Eliquis available in the United States market. Although apixaban serves as the active ingredient in Eliquis, the brand-name medication remains protected by patents. Once these patents expire, generic versions of apixaban may enter the market, potentially providing a more affordable alternative for patients. For the latest information on medication availability and alternatives, it’s essential to consult healthcare providers or pharmacists.

Eliquis Side Effects

extracting blood to his patient for Eliquis medication

Eliquis (apixaban) is generally well-tolerated, but like any medication, it may cause side effects in some people. Common side effects of blood thinner medication:

  • Bleeding: This is the most significant side effect of Eliquis, as it is an anticoagulant medication. While bleeding can occur anywhere in the body, it is most commonly seen as nosebleeds, bruising, or bleeding gums. Serious bleeding, though rare, may occur and requires immediate medical attention.

  • Easy bruising: Some people may notice increased bruising or discoloration of the skin while taking Eliquis.

  • Nausea: It may cause mild nausea in some individuals, although this side effect is not common.

  • Gastrointestinal discomfort: Some people may experience stomach discomfort, indigestion, or abdominal pain while taking blood thinner medication.

  • Headache: Headaches are another possible side effect of Eliquis, although they are usually mild and transient.

  • Dizziness: Some people may feel dizzy or lightheaded while taking Eliquis, especially when standing up quickly.

  • Fatigue: Feeling tired or fatigued is a less common side effect of Eliquis but may occur in some individuals.

Not everyone will have these side effects. Some may have others not listed. If you have unusual or bothersome symptoms while taking Eliquis, you must contact your healthcare provider. They will evaluate and guide you.

Eliquis Costs

It is priced at $159. However, when you buy it from our online pharmacy partner, 365 Script Care, you’ll receive a 10% discount on your first purchase. This brings the cost down to $143.10 plus shipping fee, offering significant savings for first-time buyers. You may seek convenience or affordability. 365 Script Care provides a trusted platform for getting your medications. Their online ordering is seamless and their delivery is reliable. You can access Eliquis at a discounted rate and get it on time. Use this offer today. You will see the convenience of ordering prescriptions online.

Eating Right with Eliquis

Remember maintaining a balanced diet while on Eliquis is crucial for optimal health. Avoid foods rich in Vitamin K. Also, drink less alcohol. This will make blood thinner medication to consult with a healthcare provider for personalized dietary recommendations. This is to ensure safety and efficacy. By choosing healthy food, individuals can support their Eliquis treatment. It will also promote their well-being.

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