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In the field of diabetes management, several medications are available to help control blood sugar levels. Two commonly prescribed drugs are Ozempic and Rybelsus. Both medications belong to a class of drugs called GLP-1 receptor agonists and are used to treat type 2 diabetes. While Ozempic and Rybelsus share similarities in their mode of action, they also have distinct features that set them apart. This article aims to provide an in-depth comparison between Ozempic and Rybelsus, highlighting their differences in terms of mechanism, benefits, side effects, dosage, cost, and patient experiences.


What is Ozempic?

Ozempic is a brand name for the generic drug semaglutide. It is an injectable medication approved by the U.S. Food and Drug Administration (FDA) for the treatment of type 2 diabetes. Ozempic belongs to the class of GLP-1 receptor agonists, which mimic the effects of a naturally occurring hormone called glucagon-like peptide-1 (GLP-1) in the body.


How Does Ozempic Work?

Ozempic works by stimulating the release of insulin from the pancreas and reducing the production of glucose in the liver. It also slows down the emptying of the stomach, which helps regulate blood sugar levels after meals. By targeting multiple aspects of glucose control, Ozempic helps improve glycemic control in individuals with type 2 diabetes.


Benefits of Ozempic

These are the benefits of Ozempic:

  • Effective blood sugar control: Ozempic has shown significant efficacy in reducing HbA1c levels, a measure of long-term blood sugar control.
  • Weight loss: Many individuals using Ozempic have experienced weight loss as a beneficial side effect.
  • Cardiovascular benefits: Studies have shown that Ozempic can reduce the risk of major adverse cardiovascular events in individuals with type 2 diabetes and established cardiovascular disease.


What is Rybelsus?

Rybelsus and Ozempic contain the same active ingredient, but Rybelsus is formulated as an oral tablet. It is FDA-approved for the treatment of Type 2 diabetes in adults, in conjunction with a healthy diet and exercise.

Rybelsus is the first oral tablet of its kind to be introduced as a medication. It is available in three varying strengths: 3 mg, 7 mg, and 14 mg.

A belly taking a shot


How Does Rybelsus Work?

Rybelsus works in a similar way to Ozempic by stimulating insulin secretion, reducing glucagon secretion, and slowing down gastric emptying. However, Rybelsus achieves these effects through its oral formulation, making it a convenient alternative for individuals who prefer oral medications over injections.


Benefits of Rybelsus

Glycemic control: Rybelsus has demonstrated efficacy in lowering HbA1c levels and improving overall blood sugar control.

Weight loss: Similar to Ozempic, Rybelsus has been associated with weight loss in individuals with type 2 diabetes.

Convenience: The oral formulation of Rybelsus offers a convenient dosing option for patients who prefer oral medications.


Effectiveness of Rybelsus vs. Ozempic

Rybelsus and Ozempic belong to the same category of medications known as glucagon-like peptide-1 (GLP-1) agonists. These drugs are included in the treatment guidelines of the American Diabetes Association (ADA) for managing type 2 diabetes. When metformin alone is not effectively lowering blood sugar levels, the ADA recommends GLP-1 agonists as an additional treatment option.

In cases where individuals with type 2 diabetes also have heart disease, the ADA guidelines suggest using a GLP-1 agonist with proven heart benefits and FDA approval for this specific purpose. However, it’s important to note that Rybelsus does not have FDA approval for treating heart disease.

Although there haven’t been direct comparative studies between Rybelsus and Ozempic, both drugs have demonstrated effectiveness in improving blood sugar levels when used in combination with diet and exercise for individuals with type 2 diabetes. For more detailed information on their performance in clinical studies, it is advisable to refer to the prescribing information provided for Rybelsus and Ozempic.


Side effects of Rybelsus vs. Ozempic

Rybelsus and Ozempic are both used to treat type 2 diabetes. While they can share some side effects, each medication may also cause different ones. Here are some of the side effects associated with these drugs:


Mild side effects

Below are lists of commonly experienced mild side effects of Rybelsus, Ozempic, and some side effects that are shared by both medications.

  • Possible side effects associated with Rybelsus:
    • Decreased appetite
  • Possible side effects associated with Ozempic
    • Reactions at the site of injection, such as skin discoloration or discomfort
  • Possible side effects associated with both Rybelsus and Ozempic:
    • Nausea and vomiting
    • Diarrhea
    • Belly pain
    • Constipation
    • Upset stomach
    • Gas
    • Weight loss

These side effects are typically temporary and may persist for a few days or weeks. If the side effects last beyond this timeframe, cause significant discomfort or worsen in severity, it is important to consult with your doctor.


Serious Side Effects

The following are serious side effects that may occur with Rybelsus and Ozempic when taken individually:

  • Hypoglycemia (low blood sugar) when used with insulin or other diabetes drugs called sulfonylureas.
  • Allergic reaction.
  • Pancreatitis (swelling or irritation of the pancreas).
  • Complications of diabetic retinopathy (a form of eye damage due to diabetes), such as worsened eyesight.
  • Sudden kidney problems.
  • Thyroid C-cell tumors

If you experience any of these serious side effects while using Rybelsus or Ozempic, contact your doctor immediately. If the side effects feel life-threatening or you believe you are having a medical emergency, call 911 or your local emergency number right away.

Doctor talking to a patient


Recommended Dosing and Administration Methods for Ozempic and Rybelsus

For Rybelsus, the typical dosing regimen involves taking 3 milligrams (mg) once daily for the initial 30 days. Following this period, your doctor will usually raise the dose to 7 mg once daily, which is generally effective for improving blood sugar control.

After taking 7 mg of Rybelsus daily for 30 days, your doctor will assess whether an increase in dose is necessary. If better blood sugar management is desired, they may prescribe a dose of 14 mg once daily.

Regarding Ozempic, the usual starting dose is a 0.25-mg injection administered once a week. After 4 weeks, your doctor will likely raise the dose to a 0.5-mg injection once a week. If further improvement in blood sugar control is needed, your doctor may increase the dose to a 1-mg injection once a week.


What interactions are there between Ozempic and Rybelsus?

When taken alone, GLP-1 receptor agonists like Ozempic and Rybelsus typically do not cause low blood sugar (hypoglycemia). However, the risk of hypoglycemia increases if they are used in combination with insulin or other insulin-releasing medications, such as sulfonylureas.

Both medications slow down the movement of contents in the stomach, which can potentially impact the absorption of other oral medications in your body. For instance, Rybelsus may reduce the absorption of levothyroxine (a thyroid medication) by approximately 33%.

To ensure safety, it is important to provide your healthcare provider and pharmacist with an up-to-date list of all the medications and supplements you are taking. This allows them to check for potential interactions and make any necessary adjustments to your medication dosages.


When to Consult Your Doctor

If you are considering starting treatment with Rybelsus or Ozempic for type 2 diabetes, or if you are thinking of switching from one medication to the other, it is important to have a discussion with your doctor. They will be able to provide guidance on which medication may be more suitable for you or if there are other diabetes treatment options that might be better suited to your needs. Your doctor will review your medical history, take into account the potential benefits and drawbacks of each drug, and provide personalized recommendations.

Here are some key points to consider when comparing the medications:

  • Both Rybelsus and Ozempic contain the same active ingredient, semaglutide.
  • Rybelsus is an oral tablet taken once a day, while Ozempic is a subcutaneous injection administered by yourself once a week.
  • If your blood sugar is not well controlled with other diabetes medications, your doctor may consider adding Rybelsus or Ozempic to your treatment plan. These drugs are typically used in combination with diet and exercise.
  • Ozempic is approved for reducing the risk of heart attack or stroke in individuals with type 2 diabetes and heart disease, whereas Rybelsus does not have this approval.

If you have any further questions about Rybelsus or Ozempic, it is recommended to consult your doctor. They can provide additional information and address any concerns you may have regarding the similarities and differences between these medications.


Switching between Rybelsus and Ozempic

Your doctor may consider switching you from Ozempic to Rybelsus if you prefer taking medication orally rather than through subcutaneous injections. Conversely, they may switch you from Rybelsus to Ozempic if you prefer the convenience of a once-a-week dosing regimen instead of taking a medication once per day.

If you have heart disease, your doctor may recommend Ozempic instead of Rybelsus. This is because Ozempic is specifically approved to reduce the risk of major heart problems in individuals with type 2 diabetes and heart disease, whereas Rybelsus does not have this approval.

The specific switching guidelines are as follows:

If you are currently taking 14 milligrams (mg) of Rybelsus once per day, your doctor may switch you to a 0.5-mg injection of Ozempic once a week. You can start the Ozempic injections the day after your last dose of Rybelsus.

If you are currently taking a 0.5-mg injection of Ozempic once a week, your doctor may switch you to either a 7-mg or 14-mg dose of Rybelsus once per day. You can start taking Rybelsus up to 7 days after your last Ozempic injection.

It’s important to note that there is no equivalent dose of Rybelsus for the 1-mg injections of Ozempic once a week.

If you are interested in switching between Rybelsus and Ozempic, it is crucial to have a discussion with your doctor. You should not make any changes to your medications without the approval and guidance of your healthcare provider. They will be able to provide appropriate recommendations based on your individual circumstances and ensure a smooth transition between the two medications.



Ozempic and Rybelsus are both effective medications for managing type 2 diabetes. While Ozempic is an injectable GLP-1 receptor agonist, Rybelsus offers the convenience of an oral formulation. Both medications have shown efficacy in lowering blood sugar levels and promoting weight loss. The choice between the two depends on individual preferences, cost considerations, and the guidance of a healthcare professional.

To purchase Ozempic or Rybelsus, you can order here at 365 Script Care. They provide reliable and licensed pharmacy services, ensuring the authenticity of the products they offer.


More articles about Ozempic:
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Ozempic Patient Assistance
Will Insurance Cover Ozempic for Prediabetes?
Ozempic or Metformin: Which is More Effective for Weight Loss?

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