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Asthma is not new to many people as this is a common condition. Living with asthma can be tough, especially when symptoms like coughing, wheezing, and shortness of breath interfere with everyday life. Fortunately, medical advancements have introduced biologic medications that can help manage asthma, especially for those with more severe cases. Biologics are special types of medications that target specific parts of the immune system that cause inflammation, which is often the root cause of asthma symptoms. 

In this article, we will focus on two important biologics: Nucala (mepolizumab) and Dupixent (dupilumab). Both of these medications are designed to help people with severe asthma breathe easier, but they work in different ways and have some unique features. By the end of this article, you will understand the key differences between Nucala and Dupixent, making it easier to talk with your doctor about which option might be best for you.

Understanding Nucala

How Nucala Works

Nucala, also known by its generic name mepolizumab, is a biologic medicine that works by targeting a type of white blood cell called eosinophils. These cells play a big role in inflammation in people with asthma. When eosinophils build up in the lungs, they can cause the airways to become swollen and tight, making it hard to breathe. 

Nucala works by blocking a protein in the body called interleukin-5 (IL-5), which is responsible for the growth and survival of eosinophils. By reducing the number of eosinophils in the body, Nucala helps decrease inflammation, which can make asthma symptoms less severe.

 

When Is Nucala Prescribed?

Nucala is usually prescribed to people with severe asthma who have a lot of eosinophils in their blood. Doctors use this medicine when other treatments, like inhalers or steroids, aren’t enough to control asthma symptoms. If you or someone you know has asthma that isn’t well controlled by regular treatments, your doctor might suggest Nucala as a next step.

 

Benefits of Nucala

The main benefit of Nucala is that it can significantly reduce the number of asthma attacks, especially for people who have a type of asthma caused by high levels of eosinophils. Some patients experience fewer trips to the emergency room, fewer days off from school or work, and overall better breathing. Many people who use Nucala also notice that they don’t need to rely as much on their rescue inhalers.

 

Side Effects and Precautions

Like all medications, Nucala can cause side effects. Some common side effects include headaches, injection site reactions (like pain or redness where the shot was given), and sometimes back pain. More serious side effects, although rare, can include allergic reactions, so it’s important to tell your doctor if you notice any unusual symptoms after starting Nucala. Your doctor will monitor your health to ensure the medication is working safely for you.

 

Understanding Dupixent

How Dupixent Works

Dupixent, or dupilumab, is another biologic medicine, but it works differently than Nucala. Dupixent targets two proteins called interleukin-4 (IL-4) and interleukin-13 (IL-13). These proteins are involved in a type of inflammation that happens in people with asthma. By blocking these proteins, Dupixent helps reduce inflammation in the airways, making it easier to breathe.

When Is Dupixent Prescribed?

Dupixent is often prescribed for people with moderate to severe asthma who have not responded well to other treatments, such as inhalers or oral steroids. It’s especially helpful for people who also have other conditions linked to asthma, like eczema (a skin condition) or nasal polyps (growths in the nose). If your asthma symptoms are out of control despite using regular medications, Dupixent might be a good option for you.

 

Benefits of Dupixent

Dupixent has been shown to reduce the number of asthma attacks and improve breathing for many people with severe asthma. It’s especially beneficial for people with other allergic conditions, like eczema or chronic sinus problems. Dupixent can improve your overall quality of life by reducing the severity of asthma symptoms and helping you feel more comfortable and active.

 

Side Effects and Precautions

While Dupixent is generally safe, it can also cause side effects. Common side effects include injection site reactions, eye problems like redness or itchiness, and cold-like symptoms. As with Nucala, serious allergic reactions are possible but rare. Always let your doctor know if you experience any unusual symptoms while using Dupixent.

 

Key Differences Between Nucala and Dupixent

Now that we’ve covered how Nucala and Dupixent work individually, let’s dive into the six key differences between these two biologics.

 

  1. Target Cells

One of the main differences between Nucala and Dupixent is the type of cells they target. Nucala targets eosinophils, a type of white blood cell that causes inflammation in the lungs. On the other hand, Dupixent targets two proteins, IL-4 and IL-13, which are responsible for a broader type of inflammation. This means that while both drugs reduce inflammation, they do so in slightly different ways depending on what is causing the inflammation in the first place.

 

  1. Mechanism of Action

Nucala works by reducing the number of eosinophils in the body, while Dupixent blocks the action of two specific proteins that contribute to inflammation. If your asthma is linked to high eosinophil levels, Nucala may be the better choice. However, if your asthma is linked to other allergic conditions like eczema, Dupixent might be a better fit.

 

  1. Approved Indications

Both Nucala and Dupixent are approved for treating severe asthma, but Dupixent has a broader range of uses. In addition to asthma, Dupixent is also approved for treating eczema and nasal polyps, while Nucala is mainly focused on asthma related to high eosinophils.

 

  1. Dosage and Administration

Nucala is typically given as an injection once every four weeks. Dupixent is also an injection, but it is usually given every two weeks, although your doctor may adjust this based on your needs. Some patients may prefer one schedule over the other depending on how often they want to receive treatment.

 

  1. Efficacy

Both Nucala and Dupixent have been shown to be effective in reducing asthma attacks and improving quality of life for patients with severe asthma. However, the choice between the two often comes down to the specific type of inflammation involved and any other medical conditions you might have. Some studies suggest that Dupixent may be more effective for people with multiple allergic conditions, while Nucala may be better for those whose asthma is driven by high eosinophil levels.

 

  1. Side Effects

While both medications have similar side effects, like injection site reactions, Dupixent is more likely to cause eye-related problems, such as redness or itching. Nucala, on the other hand, may cause more headaches. It’s important to discuss potential side effects with your doctor to figure out which medication is a better fit for you.

Choosing the Right Biologic: A Personalized Approach

Choosing between Nucala and Dupixent is not a one-size-fits-all decision. The right choice depends on your specific type of asthma, other medical conditions, and how you respond to different treatments. This is why it’s important to work closely with your healthcare provider to develop a personalized asthma management plan.

Factors like how often you experience asthma attacks, whether you have other allergies or eczema, and how you feel about receiving injections will all play a role in determining which biologic is best for you. Your doctor will take all of this into account and help guide you to the right choice.

 

Common Biologic-Related Questions and Concerns

Here are some common questions people have about biologics like Nucala and Dupixent:

 

Can I Use Both Nucala and Dupixent at the Same Time?

No, it is generally not recommended to use both Nucala and Dupixent at the same time, as they both work to reduce inflammation, but in different ways. Using both together could increase the risk of side effects without offering additional benefits.

 

What Should I Do If I Experience Side Effects?

If you experience any side effects from either Nucala or Dupixent, it’s important to tell your doctor right away. They may adjust your dosage, suggest a different treatment, or provide other options to help manage side effects.

 

Are There Any Long-Term Risks Associated With Biologic Use?

Biologics like Nucala and Dupixent are generally safe for long-term use, but as with any medication, there are risks. Some patients may develop allergic reactions, while others may experience long-term side effects that need to be monitored by their healthcare provider.

 

How Should I Store and Dispose of Biologics?

Both Nucala and Dupixent should be stored in the refrigerator and kept in their original packaging to protect them from light. When you’re ready to use them, let the medication sit at room temperature for a few minutes before injecting. Make sure to dispose of needles and syringes properly, using a sharps container.

 

Conclusion

Nucala and Dupixent are two powerful biologics that can help people with severe asthma breathe easier. While they share some similarities, they also have key differences in how they work, how they are used, and what side effects they may cause. Choosing the right biologic depends on your specific needs, and it’s important to talk with your doctor to figure out which option is best for you.

If you or someone you know is struggling with asthma that isn’t controlled by regular treatments, biologics like Nucala and Dupixent may offer a solution. Remember, managing asthma is all about finding the right treatment plan that works for your body. Always follow your doctor’s advice, keep track of your symptoms, and don’t hesitate to ask questions about your treatment options.

And if you’re considering starting biologic treatment for asthma, be sure to visit our online pharmacy referral service for safe and reliable access to medications like Nucala and Dupixent. We have healthcare professionals available to answer any questions you might have and guide you through your asthma management journey.

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