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Eli Lilly and Company introduced Humalog in 1996, marking a breakthrough in the treatment of diabetes. It was the first rapid-acting insulin analog, designed to closely mimic the body’s natural insulin response to meals.

 

What is Humalog?

Humalog is a rapid-acting insulin that begins to take effect approximately 15 minutes after injection. It reaches its peak effectiveness in about 1 hour and continues to work for 2 to 4 hours. Insulin is a hormone that functions by reducing glucose (sugar) levels in the bloodstream.

Humalog is utilized to enhance the management of blood sugar in both adults and children with diabetes mellitus. Humalog is employed in the treatment of type 2 diabetes in adults. Humalog is prescribed for individuals with type 1 diabetes, including both adults and children aged 3 years and older.

 

How to take Humalog (Insulin Lispro)?

Use Humalog (Insulin Lispro) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Insulin lispro is injected under the skin with a syringe and needle, an injection pen, or with an infusion pump. A healthcare provider will teach you how to properly use this medicine by yourself. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Prepare your injection only when you are ready to give it. Do not use it if the medicine looks cloudy, has changed colors or has particles in it. Call your pharmacist for new medicine.

Admelog or Humalog are given within 15 minutes before a meal, or right after eating. Lyumjev is given at the start of a meal or within 20 minutes after eating. Your healthcare provider will show you where on your body to inject insulin lispro. Use a different place each time you give an injection. Do not inject into the same place two times in a row. Do not inject into skin that is damaged, tender, bruised, pitted, thickened, scaly, or has a scar or hard lump.

Concentrated insulin lispro (200 units) must not be given with an insulin pump, or mixed with other insulins. Do not transfer insulin lispro from an injection pen to a syringe or a severe overdose could occur.

Never share an injection pen, cartridge, or syringe with another person, even if the needle has been changed. Sharing these devices can allow infections or disease to pass from one person to another. You may have low blood sugar (hypoglycemia) and feel very hungry, dizzy, irritable, confused, anxious, or shaky. To quickly treat hypoglycemia, eat or drink a fast-acting source of sugar (fruit juice, hard candy, crackers, raisins, or non-diet soda).

Your doctor may prescribe a glucagon injection kit in case you have severe hypoglycemia. Be sure your family or close friends know how to give you this injection in an emergency. Also, watch for signs of high blood sugar (hyperglycemia) such as increased thirst or urination. Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.

Doctor discussing the disease with a patient

Side Effects

While Humalog is generally safe, it can lead to side effects like hypoglycemia (low blood sugar), weight gain, allergic reactions, and injection site reactions. Always monitor your blood sugar levels and consult with a healthcare professional if side effects persist.

 

Risks and Warnings for Humalog 

Humalog (insulin lispro) carries the potential for serious health issues, which may be further elevated in specific groups. If you have concerns regarding these risks, it is advisable to consult your doctor or pharmacist to explore alternative options.

Sharing of Pens and Needles:

Never share Humalog (insulin lispro) pens, syringes, or needles with anyone else. Sharing these devices puts you at risk of contracting highly dangerous diseases and infections

Low Blood Sugar (Hypoglycemia):

Risk factors: Changes in diet and exercise | Alcohol consumption | Concurrent use of other diabetes medications | Being over the age of 65 | Liver or kidney problems

Humalog (insulin lispro), whether used alone or in combination with other diabetes medications, can lead to low blood sugar levels. Severe hypoglycemia can be life-threatening. Symptoms of low blood sugar include shakiness, nervousness or anxiety, rapid heartbeat, sweating or chills, confusion, drowsiness, weakness or fatigue, and excessive hunger. If you have concerns about this, consult your doctor or pharmacist.

Doctor and patient reviewing the test results

In conclusion, Humalog has transformed the lives of many individuals with diabetes, offering an effective way to manage their condition. Its unique rapid-acting properties offer improved blood glucose control, particularly around meal times. However, it’s vital to always use Humalog under the guidance of a healthcare professional due to potential side effects and precautions.

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