Trulicity is a medication prescribed to treat type 2 diabetes. It starts to work right after you inject it under the skin. However, it may take several weeks until you feel its effects. On average, its full benefits will start to kick in after 4 weeks. At this time, you will begin to experience its positive impact on your type 2 diabetes. Each patient is different and will have varying results. It is important to tell your doctor when you start feeling an improvement. You should also inform your doctor of any side effects. This way, they can properly assess if Trulicity is right for you. They can also adjust your dosage if needed.